Publications by the Canine Chiari Group

Publications by the Canine Chiari group  

  1. A data driven approach for soft tissue biomarker identification linked to Chiari-like malformation and syringomyelia Cumber J, Scales-Theobald E, Rusbridge C, Wells K Front. Vet. Sci., 22 January 2025 Sec. Veterinary Neurology and Neurosurgery Volume 11 – 2024 | https://doi.org/10.3389/fvets.2024.1492259 
  1. Characteristics and clinical course of myoclonus in Cavalier King Charles Spaniels. James M, Lowrie M, Rusbridge C. J Vet Intern Med. 2025 Jan-Feb;39(1):e17227. doi: 10.1111/jvim.17227. Epub 2024 Nov 9. PMID: 39520132; PMCID: PMC11627513. 
  1. A Novel Multiple Camera RGB-D Calibration Approach Using Simulated Annealing, M. Taghipour-Gorjikolaie, M. Volino, C. Rusbridge and K. Wells, ” in IEEE Access, vol. 12, pp. 98723-98733, 2024, doi: 10.1109/ACCESS.2024.3424412. 
  1. Clinical predictors of syringomyelia in Cavalier King Charles Spaniels with Chiari-like malformation based on owners’ observations. Pedersen TR, Bach MBT, Stougaard CL, Gredal H, Rusbridge C, Finnerup NB, Berendt M. Acta Vet Scand. 2024 Feb 8;66(1):5. doi: 10.1186/s13028-024-00725-1. PMID: 38331821; PMCID: PMC10851586. 
  1. Myoclonus in older Cavalier King Charles Spaniels C Rotter, D Whittaker, C Rusbridge Journal of Veterinary Internal Medicine  J Vet Intern Med. 2022; 36( 3): 1032- 1038. doi:10.1111/jvim.16404 
  1. Slosh Simulation in a Computer Model of Canine Syringomyelia Cirovic S, Rusbridge C. Life. 2021; 11(10):1083. https://doi.org/10.3390/life11101083 
  1. Persistent fontanelles in Chihuahuas. Part I. Distribution and clinical relevance. Kiviranta, A-M, Rusbridge, C, Lappalainen, AK, Junnila, JJT, Jokinen, TS J Vet Intern Med. 2021; 1– 14. https://doi.org/10.1111/jvim.16151 
  1. Persistent fontanelles in Chihuahuas. Part II: Association with craniocervical junction abnormalities, syringomyelia, and ventricular volume Kiviranta, A-M, Rusbridge, C, Lappalainen, AK, Junnila, JJT, Jokinen, TS. J Vet Intern Med. 2021; 1– 9. https://doi.org/10.1111/jvim.16123 
  1. The Need for Head Space: Brachycephaly and Cerebrospinal Fluid Disorders. Rusbridge C, Knowler P. Life (Basel). 2021 Feb 12;11(2):139. doi: 10.3390/life11020139. PMID: 33673129; PMCID: PMC7918167. 
  1. New considerations about Chiari-like malformation, syringomyelia and their management Rusbridge C. In Practice 2020;42:252-267. https://inpractice.bmj.com/content/42/5/252  
  1. Syringopleural shunt placement in a pug with a cervical spinal diverticulum and associated syringomyelia. Tauro, A, Rusbridge, C. Clin Case Rep. 2020; 8: 1142– 1148. https://doi.org/10.1002/ccr3.2845 
  1. Facial changes associated with brachycephaly in Chiari-like malformation associated pain and secondary syringomyelia in the Cavalier King Charles spaniel Knowler, SP, Dumas, E, Spiteri, M, McFadyen, AK, Stringer, F Wells K, Rusbridge, C. J Vet Intern Med. 2020; 34: 237– 246. https://doi.org/10.1111/jvim.15632 
  1. Using machine learning to understand neuromorphological change and image-based biomarker identification in Cavalier King Charles Spaniels with CM associated pain and syringomyelia Spiteri, M, Knowler, SP, Rusbridge, C, Wells, K. J Vet Intern Med. 2019; 33: 2665– 2674. https://doi.org/10.1111/jvim.15621  
  1. Behavioral and clinical signs of Chiari‐like malformation‐associated pain and syringomyelia in Cavalier King Charles spaniel Rusbridge, C. McFadyen, A.K., Knowler, S  J Vet Intern Med. 2019 https://doi.org/10.1111/jvim.15552 
  1. Pilot study of head conformation changes over time in the Cavalier King Charles spaniel breed. Knowler SP, Gillstedt L, Mitchell TJ, Jovanovik J, Volk HA, Rusbridge C.  Vet Rec. 2019 Jan 11;. doi: 10.1136/vr.105135. [Epub ahead of print] PubMed PMID: 30635451. 
  1. Clinical Application of Diagnostic Imaging of Chiari-Like Malformation and Syringomyelia. Rusbridge C, Stringer F, Knowler SP Front Vet Sci. 2018;5:280. doi: 10.3389/fvets.2018.00280. eCollection 2018. Review. PubMed PMID: 30547039; PubMed Central PMCID: PMC6279941. 
  1. Morphogenesis of canine Chiari malformation and secondary syringomyelia: Disorders of cerebrospinal fluid circulation. SP Knowler, GL Galea, C Rusbridge Frontiers in Veterinary Science   2018 Jul 27;5:171. doi: 10.3389/fvets.2018.00171. eCollection 2018. Review. PubMed PMID: 30101146; PubMed Central PMCID: PMC6074093. 
  1. A genome-wide association study identifies candidate loci associated to syringomyelia secondary to Chiari-like malformation in Cavalier King Charles Spaniels. Ancot F, Lemay P, Knowler SP, Kennedy K, Griffiths S, Cherubini GB, Sykes J, Mandigers PJJ, Rouleau GA, Rusbridge C, Kibar Z. BMC Genet. 2018 Mar 22;19(1):16. doi: 10.1186/s12863-018-0605-z.  
  1. Computer simulation of syringomyelia in dogs. Cirovic S , Lloyd R, Jovanovik J, Volk HA, Rusbridge C. BMC Vet Res. 2018 Mar 9;14(1):82. doi: 10.1186/s12917-018-1410-7. 
  1. Evidence of negative affective state in Cavalier King Charles Spaniels with syringomyelia Cockburn A, Smith M, Rusbridge C, Fowler C, Paul ES, Murrell JC, Blackwell, EJ, Casey RA, Whay HR, Mendle M. Applied Animal Behaviour Science https://doi.org/10.1016/j.applanim.2017.12.008 
  1. MRI characteristics for “phantom” scratching in canine syringomyelia. Nalborczyk ZR, McFadyen AK, Jovanovik J, Tauro A, Driver CJ, Fitzpatrick N, Knower SP, Rusbridge C.BMC Vet Res. 2017 Nov 16;13(1):340. doi: 10.1186/s12917-017-1258-2. 
  1. Syringomyelia and Craniocervical Junction Abnormalities in Chihuahuas. Kiviranta AM, Rusbridge C, Laitinen-Vapaavuori O, Hielm-Björkman A, Lappalainen AK, Knowler SP, Jokinen TS. J Vet Intern Med. 2017 Nov;31(6):1771-1781. doi: 10.1111/jvim.14826. Epub 2017 Sep 11.PMID: 
  1. Use of Morphometric Mapping to Characterise Symptomatic Chiari-Like Malformation, Secondary Syringomyelia and Associated Brachycephaly in the Cavalier King Charles Spaniel. Knowler SP, Cross C, Griffiths S, McFadyen AK, Jovanovik J, Tauro A, Kibar Z, Driver CJ, La Ragione RM, Rusbridge C. PLoS One. 2017 Jan 25;12(1):e0170315. doi: 10.1371/journal.pone.0170315. 
  1. Craniometric Analysis of the Hindbrain and Craniocervical Junction of Chihuahua, Affenpinscher and Cavalier King Charles Spaniel Dogs With and Without Syringomyelia Secondary to Chiari-Like Malformation. Knowler SP, Kiviranta AM, McFadyen AK, Jokinen TS, La Ragione RM, Rusbridge C. PLoS One. 2017 Jan 25;12(1):e0169898. doi: 10.1371/journal.pone.0169898. 
  1. Inheritance of Chiari-Like Malformation: Can a Mixed Breeding Reduce the Risk of Syringomyelia? Knowler SP, V/D Berg H, McFadyen A, La Ragione RM, Rusbridge C. PLoS One. 2016 Mar 23;11(3):e0151280. doi: 10.1371/journal.pone.0151280.  
  1. Prevalence of pancreatic, hepatic and renal microscopic lesions in post-mortem samples from cavalier King Charles spaniels. Kent AC, Constantino-Casas F, Rusbridge C, Corcoran BM, Carter M, Ledger T, Watson PJ. J Small Anim Pract. 2016 Apr;57(4):188-93. doi: 10.1111/jsap.12444. Epub 2016 Feb 26. 
  1. Comparison of gabapentin versus topiramate on clinically affected dogs with Chiari-like malformation and syringomyelia. Plessas IN, Volk HA, Rusbridge C, Vanhaesebrouck AE, Jeffery ND. Vet Rec. 2015 Sep 19;177(11):288. doi: 10.1136/vr.103234. Epub 2015 Aug 12 
  1. Syringomyelia: determining risk and protective factors in the conformation of the Cavalier King Charles Spaniel dog. Mitchell TJ, Knowler SP, van den Berg H, Sykes J, Rusbridge C. Canine Genetics and Epidemiology 2014;1(9). doi:10.1186/2052-6687-1-9. 
  1. Quantitative Analysis of Chiari-Like Malformation and Syringomyelia in the Griffon Bruxellois Dog SP Knowler, AK McFadyen, C Freeman, M Kent, SR Platt, Z Kibar, C Rusbridge.  
    PloS one 9 (2), e88120 
  1. Quantitative Trait Loci (QTL) Study Identifies Novel Genomic Regions Associated to Chiari-Like Malformation in Griffon Bruxellois Dogs P Lemay, SP Knowler, S Bouasker, Y Nédélec, S Platt, C Freeman, G. Child, L. B Barreiro, G A Rouleau, C Rusbridge, Z Kibar PloS one 9 (4), e89816 
  1. Chiari–like malformation and syringomyelia  C Rusbridge European Journal Companion Animal Practice 2014 23, 70-89.  
  1. Chiari- Like Malformation and Syringomyelia in American Brussels Griffon Dogs AC Freeman, SR Platt, M Kent, E Huguet, C Rusbridge, S Holmes Journal of Veterinary Internal Medicine 2014 28 (5), 1551-1559 
  1. An update on the pathogenesis of syringomyelia secondary to Chiari-like malformations in dogs 
    CJ Driver, HA Volk, C Rusbridge, LM Van Ham The Veterinary Journal, 2013 1–9. doi:10.1016/j.tvjl.2013.07.014 
  1. Progression of otitis media with effusion in the Cavalier King Charles spaniel SJ McGuinness, EJ Friend, SP Knowler, ND Jeffery, C Rusbridge Veterinary Record 2013 172 (12), 315-315  
  1. Caudal cranial fossa partitioning in Cavalier King Charles spaniels TA Shaw, IM McGonnell, CJ Driver, C Rusbridge HA Volk Veterinary Record 2013 172 (13), 341-341 
  1. Changes over time in craniocerebral morphology and syringomyelia in cavalier King Charles spaniels with Chiari-like malformation CJ Driver, L De Risio, S Hamilton, C Rusbridge, R Dennis, IM McGonnell, HA Volk BMC veterinary research 2013 8 (1), 1-7 
  1. Long-term outcome of Cavalier King Charles spaniel dogs with clinical signs associated with Chiari-like malformation and syringomyelia. Plessas IN, Rusbridge C, Driver CJ, Chandler KE, Craig A, McGonnell IM, Brodbelt DC, Volk HA. Vet Rec. 2012 Nov 17;171(20):501. doi: 10.1136/vr.100449. Epub 2012 Oct 25 
  1. Questionnaire-based behaviour analysis of Cavalier King Charles spaniels with neuropathic pain due to Chiari-like malformation and syringomyelia. Rutherford L, Wessmann A, Rusbridge C, McGonnell IM, Abeyesinghe S, Burn C, Volk HA. Vet Journal. 2012 194 (3), 294-298.  
  1. Increase in Cerebellar Volume in Cavalier King Charles Spaniels with Chiari-like Malformation and Its Role in the Development of Syringomyelia. Shaw TA, McGonnell IM, Driver CJ, Rusbridge C, Volk HA. PLoS One. 2012;7(4):e33660. Epub 2012 Apr 10. 
  1. Effectiveness of breeding guidelines for reducing the prevalence of syringomyelia. Knowler SP, McFadyen AK, Rusbridge C. Vet Rec. 2011 Dec 24-31;169(26):681. Epub 2011 Oct 13. 
  1. Distribution of substance P and calcitonin gene-related peptide in the spinal cord of Cavalier King Charles Spaniels affected by symptomatic syringomyelia.Hu HZ, Rusbridge C, Constantino-Casas F, Jeffery N. Res Vet Sci. 2012 93 (1), 318-320 
  1. Histopathological Investigation of Syringomyelia in the Cavalier King Charles Spaniel, Hu H. Z, Rusbridge C, Constantino-Casas F, Jeffery ND, J Comp Pathol. 2012 Feb;146(2-3):192-201 
  1. Prevalence of asymptomatic syringomyelia in Cavalier King Charles spaniels. Parker JE, Knowler SP, Rusbridge C, Noorman E, Jeffery ND. Veterinary Record. 2011 Jun 25;168(25):667 
  1. Distribution of syringomyelia along the entire spinal cord in clinically affected Cavalier King Charles Spaniels. Loderstedt S, Benigni L, Chandler K, Cardwell JM, Rusbridge C Lamb CR, Volk HA. Vet J. 2011 Jan 7 
  1. Morphometric assessment of cranial volumes in age-matched Cavalier King Charles spaniels with and without syringomyelia. Driver CJ, Rusbridge C, McGonnell IM, Volk HA Vet Rec. 2010 Dec 18;167(25):978-9. 
  1. Relationship of brain parenchyma within the caudal cranial fossa and ventricle size to syringomyelia in cavalier King Charles spaniels Driver C. J., Rusbridge C., Cross H. R., McGonnell I. Volk  H. A. Journal of Small Animal Practice 2010, 51, 382-386. 
  1. Heritability of syringomyelia in Cavalier King Charles spaniels. Lewis T, Rusbridge C, Knowler P, Blott S, Woolliams JA. Vet J. Vet J. 2010 Mar;183(3):345-7 
  1. [Chiari-like malformation–syringomyelia in the Cavalier King Charles Spaniel] Mandigers P, Rusbridge C. Tijdschr Diergeneeskd. 2009 Sep 15;134(18):746-50 
  1. Chiari-like malformation in the Griffon Bruxellois Rusbridge C., Knowler S. P., Pieterse L, McFadyen A. K. Journal of Small Animal Practice 2009 50 (8): 386-393  
  1. Association between cervical and intracranial dimensions and syringomyelia in the cavalier King Charles spaniel Carruthers H., Rusbridge C, Dubé M.-P., Holmes  M. Jeffery  N. Journal of Small Animal Practice 2009 50 (8): 394-398  
  1. Comparison of cerebral cranium volumes between cavalier King Charles spaniels with Chiari-like malformation, small breed dogs and Labradors Cross H. R., Cappello R., Rusbridge C.  Journal of Small Animal Practice 2009 50 (8): 399-405  
  1. Radiographic morphology of the cranial portion of the cervical vertebral column in Cavalier King Charles Spaniels and its relationship to syringomyelia. Stalin CE, Rusbridge C, Granger N, Jeffery ND. Am J Vet Res. 2008 Jan;69(1):89-93. 
  1. Chiari-like malformation with syringomyelia in the Cavalier King Charles spaniel: long-term outcome after surgical management Rusbridge C. Vet Surg. 2007 Jul;36(5):396-405. 
  1. Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain. Rusbridge C, Carruthers H, Dubé MP, Holmes M, Jeffery ND. J Small Anim Pract. 2007 Aug;48(8):432-6. Epub 2007 Jun 30. 
  1. Report from the Chiari‐Like Malformation and Syringomyelia Working Group Round Table 
    R Cappello, C Rusbridge Veterinary Surgery 36 (5), 509-512 
  1. Pathophysiology and treatment of neuropathic pain associated with syringomyelia. Rusbridge C , Jeffery ND. Vet J. 2008 Feb;175(2):164-72. Epub 2007 Feb 20.  
  1. Coexistence of occipital dysplasia and occipital hypoplasia/syringomyelia in the cavalier King Charles spaniel. Rusbridge C, Knowler SP. J Small Anim Pract. 2006 Oct;47(10):603-6. 
  1. Syringomyelia: current concepts in pathogenesis, diagnosis, and treatment. Rusbridge C, Greitz D, Iskandar BJ. J Vet Intern Med. 2006 May-Jun;20(3):469-79 
  1. Neurological diseases of the Cavalier King Charles spaniel Rusbridge C. J Small Anim Pract. 2005 Jun;46(6):265-72.  
  1. Inherited occipital hypoplasia/syringomyelia in the cavalier King Charles spaniel: experiences in setting up a worldwide DNA collection Rusbridge C. Knowler P, Rouleau GA, Minassian BA, Rothuizen J. J Hered. 2005;96(7):745-9. Epub 2005 Jun 15 
  1. Inheritance of occipital bone hypoplasia (Chiari type I malformation) in Cavalier King Charles Spaniels. Rusbridge C, Knowler SP  J Vet Intern Med. 2004 Sep-Oct;18(5):673-8.  
  1. Hereditary aspects of occipital bone hypoplasia and syringomyelia (Chiari type I malformation) in cavalier King Charles spaniels. Rusbridge C, Knowler SP, Vet Rec. 2003 Jul 26;153(4):107-12. 
  1. Dorsal dens angulation and a Chiari type malformation in a Cavalier King Charles Spaniel. Bynevelt M, Rusbridge C, Britton J. Vet Radiol Ultrasound. 2000 Nov-Dec;41(6):521-4. 
  1. Syringohydromyelia in Cavalier King Charles spaniels. Rusbridge C, MacSweeny JE, Davies JV, Chandler K, Fitzmaurice SN, Dennis R, Cappello R, Wheeler SJ. J Am Anim Hosp Assoc. 2000 Jan-Feb;36(1):34-41.